Abstract Summary

Objective: This meta-analysis examines the effects of fish oil supplementation on cardiovascular mortality.

Context: The omega-3 fatty acids EPA and DHA found abundantly in fish have demonstrated blood lipid lowering and anti-inflammatory cardiovascular protective effects. Their impact on cardiovascular mortality remains debated.

Methods Used

Approach: Pooled data analysis of 10 large-scale randomized controlled trials with 77,917 high-risk patients receiving fish oil supplementation or placebo.

Data Sources: Cardiovascular mortality data from the 10 clinical trials conducted across North America, Europe, Asia and Australia.

Researchers' Summary of Findings

Health Implications: Fish oil supplementation showed a statistically significant 8% reduction in cardiovascular death after 1 year compared to placebo, with no increased risk of major bleeding events. Supports fish oil for high-risk cardiovascular patients.

DOI: 10.1161/CIRCULATIONAHA.108.191627