Abstract Summary

Objective: This study investigates the effects of zinc supplementation on immune function in elderly adults.

Context: Zinc is an essential micronutrient that plays a pivotal role in maintaining immune health. As zinc deficiency is prevalent in older populations, this study aims to evaluate how zinc supplementation can improve immune response, particularly in reducing the occurrence of respiratory infections in the elderly.

Methods Used

Approach: A double-blind, placebo-controlled trial was conducted with 120 participants aged 65 and above. The participants were randomly assigned to receive either 30 mg of zinc gluconate daily or a placebo for six months.

Data Collection: Immune function was assessed through blood tests measuring white blood cell count, T-cell activity, and cytokine levels at baseline, three months, and six months. The frequency and severity of respiratory infections were recorded throughout the trial.

Researchers' Summary of Findings

Impact on Health: Participants in the zinc group showed a significant improvement in T-cell function and a 50% reduction in the incidence of respiratory infections compared to the placebo group. Cytokine profiles indicated a stronger immune response in the zinc-supplemented participants.

Health Implications: Zinc supplementation enhances immune function and reduces the risk of respiratory infections in elderly adults, suggesting that it could be a critical intervention for improving health outcomes in this age group.

DOI: 10.1016/j.immune.2024.112345