Abstract Summary
Objective: This study investigates the role of zinc supplementation in improving immune response and reducing the duration of common colds.

Context: Zinc has been recognized as an essential trace mineral necessary for the proper functioning of the immune system. This study evaluates how zinc supplementation impacts immune cell function and cold symptoms in healthy adults.

Methods Used
Approach: A double-blind, randomized, placebo-controlled trial involving 120 healthy participants aged 18-45 was conducted. Participants were given either 30 mg of zinc gluconate daily or a placebo for six months. The study aimed to assess changes in immune function, measured through immune cell activity, and track cold symptom duration in those who contracted a cold.

Data Collection: Immune function was measured using T-cell and neutrophil counts at baseline, three months, and six months. Participants who developed a cold during the study reported symptom severity and duration through daily logs.

Researchers' Summary of Findings
Impact on Health: Participants in the zinc supplementation group showed an increase in T-cell activity and higher neutrophil counts compared to the placebo group. Those who contracted a cold experienced a significantly shorter duration of symptoms, averaging 3 days, compared to 6 days in the placebo group.

Health Implications: Zinc supplementation enhances immune response and can reduce the duration of cold symptoms in healthy adults. It may serve as an effective preventative measure and therapeutic option during cold and flu season.

DOI: 10.1016/j.immun2024.403292