Daily Vitamin C Intake Significantly Reduces Infection Rates in Immunocompromised Adults
Abstract Summary
Objective: This study examines the impact of Vitamin C supplementation on enhancing immune function and reducing the incidence of infections in adults with compromised immune systems.
Context: Vitamin C is known for its antioxidant properties and its role in supporting the immune system. This research focuses on whether daily supplementation with high doses of Vitamin C can improve immune function and reduce the frequency of infections in adults with weakened immunity due to chronic illness or stress.
Methods Used
Approach: A double-blind, placebo-controlled study was conducted with 150 participants aged 40-65 with compromised immune systems. Participants were randomly assigned to receive either 1 gram of Vitamin C daily or a placebo for 12 weeks. Immune function was measured through T-cell activity, white blood cell counts, and the frequency of reported infections during the study period.
Data Collection: Blood samples were taken at the start, midpoint (6 weeks), and end of the study (12 weeks) to monitor immune markers such as T-cell activation, neutrophil function, and plasma Vitamin C levels. Participants also kept daily logs to record any symptoms of infections, such as fever, cough, or sore throat.
Researchers' Summary of Findings
Impact on Health: Participants in the Vitamin C group demonstrated a significant increase in T-cell activity and white blood cell counts compared to the placebo group. They also reported fewer respiratory infections over the 12-week period. Plasma Vitamin C levels were consistently higher in the supplementation group, indicating effective absorption.
Health Implications: Daily Vitamin C supplementation enhances immune function in adults with compromised immune systems and reduces the frequency of infections. This suggests that Vitamin C could be beneficial in immune support, particularly in individuals prone to frequent infections due to chronic health conditions.
DOI: 10.1016/j.immunehealth2024.508931