Abstract Summary:

• This study aimed to compare the effects of magnesium citrate, magnesium oxide, and magnesium sulfate on arterial stiffness and blood pressure.

Methods:

• In a randomized trial, 164 overweight and slightly obese participants were given either magnesium citrate, magnesium oxide, magnesium sulfate, or a placebo for 24 weeks. The daily magnesium dose was 450 mg. The primary outcome measured was carotid-to-femoral pulse wave velocity, a standard method for assessing arterial stiffness. Secondary outcomes included blood pressure and magnesium levels in plasma and urine.

Findings:

• The study found that neither magnesium citrate nor other formulations significantly impacted arterial stiffness or blood pressure compared to the placebo. However, magnesium citrate did increase plasma and urine magnesium levels more than other forms. One serious adverse event was reported but was not related to the treatment.

In conclusion, the study demonstrated that 24 weeks of oral magnesium citrate supplementation did not significantly alter arterial stiffness or blood pressure, with similar results observed for magnesium oxide and magnesium sulfate.

Link to study: Effects of Magnesium Supplementation on Arterial Stiffness