High-Dose Vitamin C Infusions May Shorten Time on Vasopressors, Study Suggests

Abstract

Objective: This study examines if high-dose vitamin C infusion improves outcomes in ICU patients with organ dysfunction syndrome.

Context: Vitamin C is an essential micronutrient with antioxidant properties that could potentially reduce inflammation and organ injury in critical illness.

Methods Used

Approach: A retrospective, propensity score-matched analysis compared ICU patients treated with and without vitamin C infusion at a dose of 50 mg/kg every 6 hours for 96 hours.

Data Collection: 94 vitamin C treated patients were matched to 94 controls. Outcomes included duration of vasopressor support, mechanical ventilation, and ICU stay.

Researchers' Summary of Findings

Impact on Health: Vitamin C infusion significantly shortened duration of vasopressor support by 18.4 hours compared to control group (p=0.04). No difference was seen for other outcomes.

Health Implications: High-dose vitamin C may help improve hemodynamics in early sepsis, but larger randomized trials are needed to confirm efficacy and safety.

DOI: 10.1097/CCM.0000000000002253