Intermittent Fasting for Obese Women: A Viable Solution?

Abstract Summary

Objective: This study investigates the effects of intermittent fasting (IF) on weight loss, body composition, and reproductive hormones in pre- and post-menopausal obese women.

Context: Intermittent fasting has gained popularity as a weight loss strategy. However, concerns exist regarding its impact on women's reproductive hormones, which are crucial for overall health and well-being. This research aims to elucidate the effects of IF on these parameters.

Methods Used

Approach: The research was an eight-week, randomized controlled trial involving 88 obese women, both pre- and post-menopausal. Participants were assigned to one of three groups: a four-hour time-restricted eating window (4-hour TRE), a six-hour time-restricted eating window (6-hour TRE), or a control group with no dietary restrictions. The 4-hour and 6-hour TRE groups followed the "warrior diet," consuming all daily calories within their respective eating windows and fasting for the remaining hours.

Data Collection: Primary outcomes included changes in body weight, body composition (assessed via dual-energy X-ray absorptiometry), and levels of reproductive hormones such as sex hormone-binding globulin (SHBG), testosterone, androstenedione, and dehydroepiandrosterone (DHEA). Assessments were conducted at baseline and after eight weeks.

Researchers' Summary of Findings

Impact on Health: Both the 4-hour and 6-hour TRE groups experienced significant reductions in body weight and fat mass compared to the control group. Notably, DHEA levels decreased by approximately 14% in both TRE groups; however, levels remained within the normal range. No significant changes were observed in SHBG, testosterone, or androstenedione levels.

Health Implications: The findings suggest that intermittent fasting, specifically time-restricted eating, can be an effective strategy for weight loss and fat reduction in obese women without adversely affecting most reproductive hormones. The observed decrease in DHEA warrants further investigation to understand its long-term implications. Overall, IF appears to be a viable option for weight management in women, with minimal impact on hormonal health.

DOI: 10.1002/oby.23527