Abstract

Objective: This randomized controlled trial investigates the effects of vitamin C supplementation on endothelial function and oxidative stress in patients with type 2 diabetes mellitus.

Context: Endothelial dysfunction and increased oxidative stress contribute to cardiovascular complications in diabetes. Vitamin C, an potent antioxidant, may have therapeutic potential, but evidence is conflicting.

Methods Used: 60 patients with type 2 diabetes were randomized to receive either 500 mg/day of vitamin C or placebo for 8 weeks. Endothelial function was assessed by flow-mediated dilation (FMD), and oxidative stress markers were measured at baseline and after intervention.

Researchers' Summary of Findings: Vitamin C supplementation significantly improved FMD compared to placebo (5.2% vs. 2.1%, p < 0.05). Levels of oxidative stress markers, such as malondialdehyde and F2-isoprostanes, were also reduced in the vitamin C group.

Health Implications: Vitamin C supplementation may improve endothelial function and reduce oxidative stress in patients with type 2 diabetes, potentially mitigating cardiovascular risk. These findings support the use of vitamin C as an adjunctive therapy in diabetes management.

DOI: 10.1016/j.diabres.2014.02.014