Abstract 1

Objective: This study investigates the antioxidant effects of vitamin C supplementation on markers of oxidative stress in patients with type 2 diabetes.

Context: Oxidative stress contributes to vascular complications in diabetes. Vitamin C is a potent antioxidant that may reduce oxidative damage. However, clinical trials show inconsistent results on oxidative stress markers.

Methods Used: A randomized, double-blind, placebo-controlled trial was conducted with 80 adults with type 2 diabetes. The intervention group received 1000 mg of vitamin C daily for 3 months. Plasma F2-isoprostanes and protein carbonyls were measured at baseline and study completion.

Researchers' Summary of Findings: Vitamin C supplementation significantly decreased plasma F2-isoprostanes by 15% compared to placebo. No significant changes occurred in protein carbonyls.

Health Implications: High-dose vitamin C reduces a marker of lipid peroxidation in patients with type 2 diabetes. This suggests antioxidant benefits that may protect against vascular damage. However, effects on protein oxidation are unclear.

DOI: 10.2337/db10-0822