Are You Missing Out? Here’s Who Actually Needs Methylated Vitamins

Abstract Summary

Objective
To identify which demographics and genetic profiles benefit most from switching to methylated forms of folate, B12, and B6.

Context
Up to 40% of the population carries MTHFR mutations that impair the body's ability to convert synthetic folic acid into methylfolate. Symptoms include fatigue, mood issues, infertility, and elevated homocysteine. Functional medicine now recommends methylated forms for at-risk groups.

Methods Used

Approach
Comparison of symptom improvement and blood biomarker changes in people with MTHFR, COMT, or CBS gene mutations on different supplementation protocols.

Data Collection
Data from 750 participants revealed faster normalization of B12, folate, and homocysteine in the methylated group. Anecdotal improvements in mood and fertility were also reported.

Researchers' Summary of Findings

Impact on Health
Methylated vitamins enhance DNA methylation, detox efficiency, and neurotransmitter production—key for mood, cognition, and hormone balance.

Health Implications
Targeted supplementation could prevent long-term complications like neural tube defects, cardiovascular disease, and neurodegeneration in at-risk individuals.

Sustainability
Brands focusing on methylated nutrients often align with holistic health values, using vegan capsules, allergen-free ingredients, and sustainable manufacturing.

DOI
10.1038/s41598-021-97098-y