Does Colostrum Help with Leaky Gut? What the 2024 Evidence Says

Abstract Summary

Objective

To assess whether bovine colostrum improves gut barrier function in adults with increased intestinal permeability due to stressors such as exercise heat stress, NSAIDs, or critical illness.

Context

Leaky gut is often indexed by urinary sugar permeability ratios or plasma I-FABP. Colostrum’s immunoglobulins and growth factors may act locally to protect epithelial integrity.

Methods Used

Approach

Evaluate standardized test outcomes pre/post colostrum vs placebo, focusing on dose, duration, and heat/illness stress contexts.

Data Collection

The meta-analysis pooled 10 trials and reported a significant reduction in permeability ratios after colostrum, with no clear effect on I-FABP; individual RCTs using ~20 g/day for ~14 days curtailed heat-exercise–induced gut injury; ICU trials using 20 g/day showed improved permeability indices.

Researchers' Summary of Findings

Impact on Health

Improving barrier function may reduce translocation of luminal antigens and endotoxins, potentially easing GI symptoms under stress and supporting recovery.

Health Implications

Adults seeking gut support may consider evidence-aligned dosing for limited periods and monitor symptoms; those with complex GI disease should coordinate with clinicians.

Sustainability

Given large between-product differences in bioactivity, favor manufacturers with transparent sourcing and batch-level potency testing to ensure reproducible effects.

DOI

10.1007/s10620-023-08219-2