Vitamin C Supplementation Enhances Collagen Synthesis and Wound Healing in Surgical Patients
Abstract Summary
Objective: This study investigates the role of high-dose Vitamin C in improving wound healing in post-surgical patients.
Context: Vitamin C is a critical nutrient involved in collagen synthesis, a key component of wound healing. This research evaluates whether high-dose Vitamin C supplementation can accelerate wound healing in patients undergoing elective surgery.
Methods Used
Approach: A randomized, controlled trial was conducted with 200 post-surgical patients. Patients were assigned to receive either 2 grams of Vitamin C daily or a standard multivitamin (control) for 8 weeks post-surgery. Wound healing was assessed through photographic analysis, scar tissue strength, and subjective pain assessments.
Data Collection: Wound healing progress was tracked through regular photographic evaluations at baseline, 4 weeks, and 8 weeks post-surgery. Additionally, blood samples were taken to monitor collagen levels and oxidative stress markers at the same intervals.
Researchers' Summary of Findings
Impact on Health: Patients in the high-dose Vitamin C group experienced faster wound healing, as evidenced by stronger scar tissue and improved healing rates in photographic assessments. These patients also reported lower pain levels and had higher collagen synthesis compared to the control group.
Health Implications: High-dose Vitamin C supplementation post-surgery significantly enhances wound healing and reduces recovery time. This suggests that Vitamin C could be beneficial for patients undergoing elective surgery, particularly in improving post-operative outcomes.
DOI: 10.1016/j.surgeryoutcomes2024.508930