Who Should Not Take Prebiotics?

Abstract Summary

Objective

To identify populations that may experience negative effects from prebiotic intake and clarify when avoidance or caution is necessary.

Context

Prebiotics are non-digestible fibers that promote microbial fermentation in the gut. While beneficial for many, excessive fermentation can worsen symptoms in individuals with specific gastrointestinal or metabolic conditions.

Methods Used

Approach

Clinical observations and dietary intervention studies were analyzed to assess symptom changes in individuals consuming common prebiotics such as inulin, FOS, and GOS.

Data Collection

Data included patient-reported outcomes, hydrogen breath testing, bloating severity scales, and inflammatory marker assessments across multiple controlled trials.

Researchers' Summary of Findings

Impact on Health

For sensitive populations, prebiotics may increase bloating, gas, abdominal pain, and diarrhea due to excessive microbial fermentation.

Health Implications

Avoidance or professional supervision is recommended for individuals with chronic gut disorders. Gradual dietary fiber intake from whole foods may be safer than supplements.

Sustainability

Personalized nutrition strategies reduce unnecessary supplement use, minimizing waste and promoting more sustainable dietary practices.

DOI

https://doi.org/10.1016/j.cgh.2022.08.014

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