Study Title:

"Dietary Magnesium Intake and the Risk of Cardiovascular Disease, Type 2 Diabetes, and All-Cause Mortality: A Dose-Response Meta-Analysis of Prospective Cohort Studies"

Authors: Fudi Wang, Yingying Ouyang, Jun Liu, Minmin Zhu, Gan Zhou, Wenwen Du, Lijun Shen, Frank B. Hu.

Abstract Summary:

• The meta-analysis aimed to quantify the dose-response association between dietary magnesium intake and the risk of cardiovascular disease (CVD), type 2 diabetes (T2D), and all-cause mortality.
• The research suggested that higher dietary magnesium intake is significantly inversely associated with the risk of these health outcomes.

Methods Used:

• Databases such as PubMed, Embase, and Web of Science were systematically searched for relevant studies up to February 2016.
• The inclusion criteria were prospective cohort studies that provided relative risks (RRs) with 95% confidence intervals (CIs) for the health outcomes of interest.
• A random-effects model was employed to compute pooled RRs.
• Non-linear dose-response analyses were also conducted to explore the relationship between magnesium intake and the risk of the outcomes.

Researchers' Summary of Findings:

• Cardiovascular Disease: For each 100 mg/day increase in magnesium intake, the risk of CVD decreased by approximately 10%.
• Type 2 Diabetes: The risk of T2D showed a significant reduction of 19% for each 100 mg/day increment in magnesium intake.
• All-Cause Mortality: Each 100 mg/day increase in magnesium intake was correlated with a 10% reduction in all-cause mortality.
• Dose-Response Relationship: There appeared to be a threshold effect, with the benefits plateauing at a magnesium intake of approximately 250 mg/day for CVD risk and 350 mg/day for T2D risk.

Conclusion:

The study concluded that dietary magnesium intake is inversely associated with the risk of CVD, T2D, and all-cause mortality, and these findings support the need for policy strategies to increase dietary magnesium intake to promote cardiovascular health and prevent chronic diseases.