What Does Reishi Do to the Brain?

Abstract Summary

Objective

To clarify the mechanisms through which reishi mushroom influences brain function and identify outcomes supported by current evidence.

Context
Traditional medicine regards reishi as a “shen tonic”—a substance calming to the spirit and mind. Modern research focuses on its polysaccharides and triterpenes that may modulate neurotransmitters and reduce neuroinflammatory states.

Methods Used

Approach

Analysis of neurological biomarkers, memory and learning performance, and anti-inflammatory activity in both preclinical and clinical settings.

Data Collection
Data included animal cognitive performance tests, human subjective assessments of mood and cognition, as well as brain tissue analyses of inflammation and neurogenesis markers.

Researchers’ Summary of Findings

Impact on Health
Reishi compounds, particularly triterpenoids, show promise in protecting neurons from oxidative stress, enhancing cholinergic activity, and promoting hippocampal neurogenesis in animal models.

Health Implications
While early data is encouraging, human studies remain limited. Reishi may enhance stress resilience and support brain aging, but should be viewed as a supportive agent rather than a standalone treatment.

Sustainability
Reishi sourced through controlled organic cultivation with ethanol and water extraction preserves neuroactive constituents while ensuring product purity and safety.

DOI
https://doi.org/10.3390/nu14051030

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