Abstract Summary

Objective: This study evaluates the efficacy of high-dose intravenous vitamin C as an adjuvant therapy for sepsis and acute respiratory distress syndrome.

Context: Sepsis and sepsis-induced ARDS are leading causes of death in critically ill patients. Oxidative damage plays an important role in their pathogenesis. Vitamin C is a potent antioxidant with pleiotropic biological effects.

Methods Used

Approach: A double-blind, randomized, placebo-controlled trial with 24 patients who had sepsis and ARDS receiving either intravenous vitamin C or placebo for 96 hours.

Data Sources: Primary data on organ dysfunction scores from the 24 patients in the clinical trial.

Researchers' Summary of Findings

Health Implications: Patients who received intravenous vitamin C had faster resolution of organ dysfunction compared to those receiving placebo over the 96 hour study period. No differences were observed in fluid volume or vasopressor requirements.

DOI: 10.1097/CCM.0000000000002198